We do both basic and applied research in Microbiology and have various national and international projects. Corpogen has three research groups:

 

 

  • Molecular Biotechnology
  • Molecular Genetics
  • Bioinformatics
 

See recent publications

Research

Projects

Resistance and adaptation

  • Acquisition of resistance and persistance in Klebsiella pneumoniae clincal isolates

  • Microbial communities associated with endotracheal tubes in ICU patients

  • ARGs in the Bogotá River

Microbial diversity

  • Identification and conservation of microorganisms isolated from soil and water from extreme habitats in Colombia

  • Lichen microbial communities

  • Microorganismos in the bus transport system

Mycobacterium tuberculosis Biomarkers

  • Molecular diagnostics 

  • Transcriptomics

Metabolites and microbial enzymes

  • Study of biosynthetic gene clusters in Streptomyces strains

  • Microbial enzymes to promote industrial mushroom cultivation

  • Development of a transposon tool for enhanced gene expression from metagenomic libraries

Bioinformatics

  • Metabolic potential present in genomes and metagenomes

  • Identification of enzymes in metagenomes

Recent Publications

 
  • Genetic and Bioinformatic Strategies to Improve Diagnosis in Three Inherited Bleeding Disorders in Bogotá, Colombia. Lago et al. Genes (Basel). 2021 Nov 18; 12 (11): 1807. doi: 10.3390 / genes12111807.

  • Annotating unknown species of urban microorganisms on a global scale unveils novel functional diversity and local environment association. Wu et al. Environ Res. 2021 Oct 9; 112183. doi: 10.1016 / j.envres.2021.112183.

  • A global metagenomic map of urban microbiomes and antimicrobial resistance. Danko et al. Cell. 2021 Jun 24; 184 (13): 3376-3393.e17. doi: 10.1016 / j.cell.2021.05.002. Epub 2021 May 26.

  • Dissecting industrial fermentations of fine flavor cocoa through metagenomic analysis. Fernández-Niño et al.  Sci Rep. 2021 Apr 21; 11 (1): 8638. doi: 10.1038 / s41598-021-88048-3.

  • COVID-19 drug practices risk antimicrobial resistance evolution. Afshinnekoo et al. Lancet Microbe. 2021 Apr; 2 (4): e135-e136. doi: 10.1016 / S2666-5247 (21) 00039-2. Epub 2021 Feb 24.

  • The effect of aminoglycosides on horizontal gene transfer in Klebsiella pneumoniae. Acosta IA et al. Rev. Acad. Colomb. Science. Ex. Fis. Nat. 2020. 44 (170): 105-120. Cell. 2021 Jun 24; 184 (13): 3376-3393.e17. doi: 10.1016 / j.cell.2021.05.002. Epub 2021 May 26.

  • The Microbiomes of Seven Lichen Genera Reveal Host Specificity, a Reduced Core Community and Potential as Source of Antimicrobials. Sierrra MA et al. Front. Microbiol. 2020. 11: 398. doi: 10.3389 / fmicb.2020.00398

  • Detection and Quantification of HspX Antigen in Sputum Samples Using Plasmonic Biosensing: Toward a Real Point-of-Care (POC) for Tuberculosis Diagnosis. Pelaez et al. ACS Infect Dis. 2020 May 8; 6 (5): 1110-1120. doi: 10.1021 / acsinfecdis.9b00502. Epub 2020 Apr 14.

  • Design and validation of a transposon that promotes expression of genes in episomal DNA. Mongui et al. J Biotechnol. 2020 Feb 20; 310: 1-5. doi: 10.1016 / j.jbiotec.2020.01.007. Epub 2020 Jan 16.

  • Computational search for UV radiation resistance strategies in Deinococcus swuensis isolated from Paramo ecosystems. Diaz-Riaño. PLoS One. 2019 Dec 2; 14 (12): e0221540.doi: 10.1371 / journal.pone.0221540. eCollection 2019.

  • Bogotá River anthropogenic contamination alters microbial communities and promotes spread of antibiotic resistance genes. Posada-Perlaza CE et al. Sci Rep. 2019 Aug 13; 9 (1): 11764. doi: 10.1038 / s41598-019-48200-6. PMID: 31409850

  • Global phylogeography and ancient evolution of the widespread human gut virus crAssphage. Edwards RA et al. Nat Microbiol. 2019 Oct; 4 (10): 1727-1736. doi: 10.1038 / s41564-019-0494-6. PMID: 31285584.

  • Recovery and functional validation of hidden soil enzymes in metagenomic libraries. Calderon D et al. MicrobiologyOpen. 2019 Apr; 8 (4): e00572. doi: 10.1002 / mbo3.572. Epub 2019 Mar 9. PMID: 30851083

 

  • Hypoxia Is Not a Main Stress When Mycobacterium tuberculosis Is in a Dormancy-Like Long-Chain Fatty Acid Environment. Del Portillo P et al. Front Cell Infect Microbiol. 2019 Jan 9; 8: 449. doi: 10.3389 / fcimb.2018.00449. eCollection 2018. PMID: 30687646