Research

 

We do both basic and applied research in Microbiology and have various national and international projects. Corpogen has three research groups:

  • Molecular Biotechnology
  • Molecular Genetics 
  • Bioinformatics

See recent publications

Projects

Microbial resistance and adaptation

  • Resistance in the environment

  • Biofilms and microbial communities associated with orotracheal tubes in patients in intensive care units.

microbial diversity

  • Identification and conservation of microorganisms isolated from soils and waters of various extreme habitats in the country.  

  • Microbial communities associated with pianguas in the Pacific

  • Microorganisms in the Transmilenio bus system in Bogotá

 

Biomarkers and diagnostics

  • Molecular diagnosis of M. tuberculosis

  • Transcriptomics in M. tuberculosis

  • Diagnoses of viral diseases in Colombia

Metabolites and microbial enzymes

  • Identification and study of biosynthetic genes in Streptomyces strains

  • Study of microbial enzymes to favor edible mushroom cultures

  • Development of a molecular system to increase gene expression in metagenomic libraries. 

Bioinformatics

  • Metabolic potential present in genomes and metagenomes

  • Identification of enzymes in metagenomes

Recent Publications

 
  • Close Related Drug-Resistance Beijing Isolates of Mycobacterium tuberculosis Reveal a Different Transcriptomic Signature in a Murine Disease Progression Model. Cerezo-Cortés MI et al. Int J Mol Sci. 2022 May 5;23(9):5157. doi: 10.3390/ijms23095157. PMID: 35563545

  • Multilateral benefit-sharing from digital sequence information will support both science and biodiversity conservation. Scholz AH et al. Nat Commun. 2022 Feb 23;13(1):1086. doi: 10.1038/s41467-022-28594-0. PMID: 35197464

  • Heterogeneous fitness landscape cues, pknG low expression, and phthiocerol dimycocerosate low production of Mycobacterium tuberculosis ATCC25618 rpoB S450L in enriched broth. Rodríguez-Beltrán É et al. Tuberculosis (Edinb). 2022 Jan;132:102156. doi: 10.1016/j.tube.2021.102156. Epub 2021 Dec 3. PMID: 34891037

  • Genetic and Bioinformatic Strategies to Improve Diagnosis in Three Inherited Bleeding Disorders in Bogotá, Colombia. Lago et al. Genes (Basel). 2021 Nov 18;12(11):1807. doi: 10.3390/genes12111807.

  • Annotating unknown species of urban microorganisms on a global scale unveils novel functional diversity and local environment association. Wu et al. Environ Res. 2021 Oct 9;112183. doi: 10.1016/j.envres.2021.112183.

  • A global metagenomic map of urban microbiomes and antimicrobial resistance. Danco et al. Cell. 2021 Jun 24;184(13):3376-3393.e17. doi: 10.1016/j.cell.2021.05.002. Epub 2021 May 26.

  • Dissecting industrial fermentations of fine flavor cocoa through metagenomic analysis. Fernández-Niño et al.  Sci Rep. 2021 Apr 21;11(1):8638. doi: 10.1038/s41598-021-88048-3.

  • COVID-19 drug practices risk antimicrobial resistance evolution. Afshinnekoo et al. Lancet Microbe. 2021 Apr;2(4):e135-e136. doi: 10.1016/S2666-5247(21)00039-2. Epub 2021 Feb 24.

  • The effect of aminoglycosides on horizontal gene transfer in Klebsiella pneumoniae. Acosta IA et al. Rev. Acad. Columbia. Science. Ex. Phys. Nat. 2020. 44(170):105-120.Cell. 2021 Jun 24;184(13):3376-3393.e17. doi: 10.1016/j.cell.2021.05.002. Epub 2021 May 26.

  • The Microbiomes of Seven Lichen Genera Reveal Host Specificity, a Reduced Core Community and Potential as Source of Antimicrobials. Sierra MA et al. Front. microbiol. 2020. 11:398. doi: 10.3389/fmicb.2020.00398

  • Detection and Quantification of HspX Antigen in Sputum Samples Using Plasmonic Biosensing: Toward a Real Point-of-Care (POC) for Tuberculosis Diagnosis. Pelaez et al. ACS Infect Dis. 2020 May 8;6(5):1110-1120. doi: 10.1021/acsinfecdis.9b00502. Epub 2020 Apr 14.

  • Design and validation of a transposon that promotes expression of genes in episomal DNA. Mongui et al. J Biotechnol. 2020 Feb 20;310:1-5. doi: 10.1016/j.jbiotec.2020.01.007. Epub 2020 Jan 16.